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© Christine Schmitt, Anubis Vega Rua, Jean-Marc Panaud
Tête de moustique femelle Aedes albopictus, vecteur du virus de la dengue et du chikungunya. Microphotographie électronique à balayage, image colorisée.
Publication : Emerging microbes & infections

Evolution and biological significance of flaviviral elements in the genome of the arboviral vector

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Emerging microbes & infections - 01 Jan 2019

Houé V, Gabiane G, Dauga C, Suez M, Madec Y, Mousson L, Marconcini M, Yen PS, de Lamballerie X, Bonizzoni M, Failloux AB

Link to Pubmed [PMID] – 31469046

Emerg Microbes Infect 2019;8(1):1265-1279

Since its genome details are publically available, the mosquito has become the central stage of attention for deciphering multiple biological and evolutionary aspects at the root of its success as an invasive species. Its genome of 1,967 Mb harbours an unusual high number of non-retroviral integrated RNA virus sequences (NIRVS). NIRVS are enriched in piRNA clusters and produce piRNAs, suggesting an antiviral effect. Here, we investigated the evolutionary history of NIRVS in geographically distant populations by comparing genetic variation as derived by neutral microsatellite loci and seven selected NIRVS. We found that the evolution of NIRVS was far to be neutral with variations both in their distribution and sequence polymorphism among populations. The Flaviviral elements AlbFlavi2 and AlbFlavi36 were more deeply investigated in their association with dissemination rates of dengue virus (DENV) and chikungunya virus (CHIKV) in at both population and individual levels. Our results show a complex association between NIRVS and DENV/CHIKV opening a new avenue for investigating the functional role of NIRVS as antiviral elements shaping vector competence of mosquitoes to arboviruses.

https://www.ncbi.nlm.nih.gov/pubmed/31469046