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© Research
Publication : Nature genetics

Essentiality, not expressiveness, drives gene-strand bias in bacteria

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature genetics - 01 Aug 2003

Rocha EP, Danchin A

Link to Pubmed [PMID] – 12847524

Nat. Genet. 2003 Aug;34(4):377-8

Preferential positioning of bacterial genes in the leading strand was thought to result from selection to avoid high head-on collision rates between DNA and RNA polymerases. Here we show, however, that in Bacillus subtilis and Escherichia coli, essentiality (the transcript product), not expressiveness (the collision rate), selectively drives the biased gene distribution.

http://www.ncbi.nlm.nih.gov/pubmed/12847524