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© Research
Publication : Transactions of the Royal Society of Tropical Medicine and Hygiene

Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Transactions of the Royal Society of Tropical Medicine and Hygiene - 01 Feb 2005

Fontanet AL, Houzé S, Keundjian A, Schiemann R, Ralaimazava P, Durand R, Cha O, Coulaud JP, Le Bras J, Bouchaud O

Link to Pubmed [PMID] – 15607335

Trans. R. Soc. Trop. Med. Hyg. 2005 Feb;99(2):91-100

Controversy exists about which antimalarial chemoprophylaxis regimen should be used among travellers to Africa: the WHO and other experts recommend the use of mefloquine throughout sub-Saharan Africa, whereas French experts still support the combination of chloroquine and proguanil in most of West Africa (the so-called zone 2 countries). In this case-control study based at a travel clinic, we examined the compliance with antimalarial chemoprophylaxis and its efficacy among travellers to tropical areas. Cases were patients with Plasmodium falciparum malaria (n = 131). Controls were patients who had a negative malaria film (n = 158). Of all controls, only 36 (22.8%) were adequately protected (i.e. compliant with an adapted regimen of chemoprophylaxis). In zone 2 countries, the efficacy of the combined chloroquine and proguanil was 58% (95% CI 22-78%) for all users, but increased to 100% (95% CI 89-100%) for compliant users. In zone 3 countries, the efficacy of mefloquine was 90% (95% CI 51-98%) and 100% (95% CI 58-100%) for all users and compliant users, respectively.

http://www.ncbi.nlm.nih.gov/pubmed/15607335