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© Research
Publication : Scandinavian journal of immunology

Effects of hydroxyurea on concanavalin-A-induced T-cell proliferation. Depletion of T-cell growth factor-reactive and -producing T lymphocytes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scandinavian journal of immunology - 01 Apr 1984

Rocha B, Larsson EL, Freitas AA

Link to Pubmed [PMID] – 6610204

Scand. J. Immunol. 1984 Apr;19(4):315-21

The effects of eliminating cycling precursors by in vivo administration of high doses of hydroxyurea (HU) in populations of mouse spleen T lymphocytes were studied by membrane immunofluorescence identifying mature Thy 1+, Lyt 2- and Lyt 2+ cell populations and mitogen-induced T-cell growth factor (TCGF) production or reactivity to TCGF. HU treatment results in a sharp decrease in the total number of T cells in mouse spleen, indicating that about 50% of peripheral splenic T lymphocytes have a short survival time in vivo. This depletion is more marked for Lyt 2+ cells than for Lyt 2- cells. The decay of TCGF-reactive spleen cells after drug administration is similar to that of the overall spleen T-cell population. Conversely, production of TCGF induced by concanavalin A is predominantly affected by HU treatment, indicating a shorter life span of the cell(s) involved in TCGF production.

http://www.ncbi.nlm.nih.gov/pubmed/6610204