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© Research
Publication : Cancer investigation

Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis.

Team: Group: Infection, Genotoxicity and Cancer
Member: Eliette Touati
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cancer investigation - 01 Feb 2021

Alikhani M, Touati E, Karimipoor M, Vosough M, Eybpoosh S, Mohammadi M

Link to Pubmed [PMID] – 33290105

Link to DOI – 10.1080/07357907.2020.1857394

Cancer Invest 2021 Feb; 39(2): 163-179

We have performed a systematic review and meta-analysis for evaluation of mitochondrial DNA copy number (mtDNA-CN) alterations in peripheral blood leukocytes (PBL), and tumor tissues of gastrointestinal tract (GIT) cancers. Analysis of the PBL demonstrated a significant decrease [OR: 0.6 (0.5, 0.8)] and increase [OR: 1.4 (1.1, 1.9)] prior to and following GIT cancer development, respectively. This trend was more evident in CRC, and GC subgroups. Analysis of tissue yielded high levels of heterogeneity. However, the mean difference for the CRC subgroup was statistically significant [1.5 (1.0, 2.2)]. Our analysis suggests mtDNA-CN deserves further investigations as a GIT-cancer screening tool.