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whocc
project
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Administrative Staff
Assistant Professor
Associate Professor
Clinical Research Assistant
Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
Full Professor
Honorary Professor
Lab assistant
Master Student
Non-permanent Researcher
Nursing Staff
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

Appointments

Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Uncorrected errors and correct saccades in the antisaccade task distinguish between early-stage Alzheimer’s disease dementia, amnestic mild cognitive impairment, and normal aging.

Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero.

© Research

Publication : Open forum infectious diseases

Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis.

Team: Immunobiology of Aspergillus

Member: Vishu Kumar Aimanianda Bopaiah

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Diseases

Organisms

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Technique

Published in Open forum infectious diseases - 01 Apr 2023

Lortholary O, El-Sissy C, Leporrier J, Sze Wah Wong S, Dannaoui E, Fremeaux-Bacchi V, Aimanianda V

Link to Pubmed [PMID] – 37065989

Link to DOI – 10.1093/ofid/ofad159

Open Forum Infect Dis 2023 Apr; 10(4): ofad159

Eculizumab, a recombinant humanized monoclonal antibody (mAb), is used for the treatment of patients (both adults and children) with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. This mAb binds to complement protein 5 (C5), thereby inhibiting its cleavage. On the other hand, one of the C5 cleavage products, C5a, is a potent anaphylatoxin with proinflammatory properties, involved in antimicrobial surveillance. Administration of eculizumab has been reported to make patients more susceptible to infection by encapsulated bacteria. Here, we are reporting an adult case of disseminated infection due to the encapsulated yeast Cryptococcus neoformans following eculizumab therapy and discuss its pathogenesis.

Published on: 01 Apr 2023