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  • Director of Center
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© Research
Publication : Open forum infectious diseases

Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Open forum infectious diseases - 01 Apr 2023

Lortholary O, El-Sissy C, Leporrier J, Sze Wah Wong S, Dannaoui E, Fremeaux-Bacchi V, Aimanianda V

Link to Pubmed [PMID] – 37065989

Link to DOI – 10.1093/ofid/ofad159

Open Forum Infect Dis 2023 Apr; 10(4): ofad159

Eculizumab, a recombinant humanized monoclonal antibody (mAb), is used for the treatment of patients (both adults and children) with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. This mAb binds to complement protein 5 (C5), thereby inhibiting its cleavage. On the other hand, one of the C5 cleavage products, C5a, is a potent anaphylatoxin with proinflammatory properties, involved in antimicrobial surveillance. Administration of eculizumab has been reported to make patients more susceptible to infection by encapsulated bacteria. Here, we are reporting an adult case of disseminated infection due to the encapsulated yeast Cryptococcus neoformans following eculizumab therapy and discuss its pathogenesis.