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© Research
Publication : Memorias do Instituto Oswaldo Cruz

Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome.

Reference Center: Invasive Mycoses and Antifungals
Member: Olivier Lortholary
Member: Alexandre Alanio
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Memorias do Instituto Oswaldo Cruz - 07 May 2018

Chammard TB, Temfack E, Lortholary O, Alanio A,

Link to Pubmed [PMID] – 29742199

Link to DOI – S0074-0276201800070020710.1590/0074-02760180050

Mem. Inst. Oswaldo Cruz 2018 ; 113(7): e180050

Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using “test and treat” screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptococcal meningitis (CM) in HIV-infected patients. Recommended induction, consolidation, and maintenance therapeutic strategy for CM is widely unavailable and/or expensive in low and middle-income settings. New therapeutic strategies, mostly using reduced duration, have recently shown acceptable outcome or are currently tested. Diagnostic and therapeutic guidelines for cryptococcal disease in limited resources countries are undergoing a paradigmatic shift.