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© Research
Publication : Seminars in immunology

Development and function of tissue resident macrophages in mice

Team: Macrophages and Endothelial Cells
Member: Elisa Gomez Perdiguero
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Seminars in immunology - 29 Mar 2016

Kierdorf K, Prinz M, Geissmann F, Gomez Perdiguero E

Link to Pubmed [PMID] – 27036090

Semin. Immunol. 2015 Dec;27(6):369-78

Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversity of tissue resident macrophages. Here, we want to present the current view on macrophage development and tissue specification and we will discuss differences as well as common patterns between heterogeneous macrophage subpopulations.