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© Research
Publication : Immunological reviews

Development and evolution of RORγt+ cells in a microbe’s world

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunological reviews - 01 Jan 2012

Eberl G

Link to Pubmed [PMID] – 22168420

Immunol. Rev. 2012 Jan;245(1):177-88

The nuclear hormone receptor retinoid-related orphan receptor γt (RORγt) induces a pro-inflammatory program in lymphoid cells, culminating in the expression of interleukin-6 (IL-6), IL-17, IL-22, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor. During ontogeny, the first type of cells expressing RORγt are lymphoid tissue inducer cells, a type of innate lymphoid cell (ILC) generated in mammalian fetuses to induce the development of lymph nodes and Peyer’s patches. After birth, RORγt(+) ILCs and RORγt(+) T cells are involved in the defense of epithelial surfaces against extracellular microbes and play an important role in the intestinal homeostasis with symbiotic microbiota. The development and evolution of RORγt(+) cells is intimately associated with the construction of a stable host-microbe interface.

http://www.ncbi.nlm.nih.gov/pubmed/22168420