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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Publication : Microbes and infection / Institut Pasteur

Dengue-3 virus genomic differences that correlate with in vitro phenotype on a human cell line but not with disease severity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbes and infection / Institut Pasteur - 12 Dec 2006

Roche C, Cassar O, Laille M, Murgue B

Link to Pubmed [PMID] – 17196421

Microbes Infect. 2007 Jan;9(1):63-9

We compared the full genome sequence of nine clinical isolates of dengue virus obtained during an epidemic of dengue-3 in French Polynesia in 1989, from patients with various presentations of disease. The isolates, all belonging to Genotype I, had 25 amino acid substitutions. There was no association with disease severity. When cultured in the K562 human erythroleukemia cell line, the isolates induced a range of cell growth inhibitions that was not associated with the degree of disease severity. By contrast, some substitutions–charge changes in NS1 and NS5, side-chain differences in NS1, loss of the E-153 potential glycosylation site, and 11 nucleotide insertions in the 3’UTR–that have been suggested to result in an increase or attenuation of dengue infection, appeared to be associated with the level of inhibition. These data represent the first documented study of an association between differences in the full dengue-3 genome of clinical isolates and the in vitro phenotype of these isolates on a human cell line.

http://www.ncbi.nlm.nih.gov/pubmed/17196421