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© A. Alanio, E. Perret
Prolifération de Cryptococcus neoformans dans des macrophages murins.
Publication : Annales de pathologie

[Cryptococcus where they are not expected: Five case reports of extra-cerebral and extra-pulmonary cryptococcosis].

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annales de pathologie - 01 Dec 2015

Cazorla A, Alanio A, Bretagne S, Polivka M, Shaar-Chneker C, Kaci R, Brouland JP, Chrétien F, Jouvion G,

Link to Pubmed [PMID] – 26596691

Link to DOI [DOI] – 10.1016/j.annpat.2015.10.001S0242-6498(15)00207-2

Ann Pathol 2015 Dec; 35(6): 479-85

Cryptococcosis is a serious infection, possibly lethal, of worldwide distribution. It mainly affects immunosuppressed patients resulting with pulmonary and/or meningeal involvements or disseminated infections. Due to the rarity of visceral and osseous infections, and to the absence of specific clinical symptoms, this diagnosis is often deferred. Resulting of diagnostic errors, samples are often directed to the department of pathology and more rarely to the department of mycology. Histopathological examination appears crucial, highlighting encapsulated yeasts with alcian blue staining. Once the diagnosis is performed, an appropriate antifungal therapy must be quickly introduced because these infections are associated with a high mortality rate. The aim of our work was to report five extra-cerebral and extra-pulmonary cryptococcosis cases, to describe their histopathological features, to evoke diagnostic techniques and to discuss the differential diagnoses.

https://pubmed.ncbi.nlm.nih.gov/26596691