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© Research
Publication : The Journal of cell biology

Cortactin and dynamin are required for the clathrin-independent endocytosis of gammac cytokine receptor

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of cell biology - 28 Dec 2004

Sauvonnet N, Dujeancourt A, Dautry-Varsat A

Link to Pubmed [PMID] – 15623579

J. Cell Biol. 2005 Jan;168(1):155-63

Endocytosis is critical for many cellular functions. We show that endocytosis of the common gammac cytokine receptor is clathrin independent by using a dominant-negative mutant of Eps15 or RNA interference to knock down clathrin heavy chain. This pathway is synaptojanin independent and requires the GTPase dynamin. In addition, this process requires actin polymerization. To further characterize the function of dynamin in clathrin-independent endocytosis, in particular its connection with the actin cytoskeleton, we focused on dynamin-binding proteins that interact with F-actin. We compared the involvement of these proteins in the clathrin-dependent and -independent pathways. Thus, we observed that intersectin, syndapin, and mAbp1, which are necessary for the uptake of transferrin (Tf), a marker of the clathrin route, are not required for gammac receptor endocytosis. Strikingly, cortactin is needed for both gammac and Tf internalizations. These results reveal the ubiquitous action of cortactin in internalization processes and suggest its role as a linker between actin dynamics and clathrin-dependent and -independent endocytosis.

http://www.ncbi.nlm.nih.gov/pubmed/15623579