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© Research
Publication : Trends in endocrinology and metabolism: TEM

Coregulators: transducing signal from transcription to alternative splicing

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in endocrinology and metabolism: TEM - 21 Feb 2007

Auboeuf D, Batsché E, Dutertre M, Muchardt C, O'Malley BW

Link to Pubmed [PMID] – 17320409

Trends Endocrinol. Metab. 2007 Apr;18(3):122-9

Cells respond to many external stimuli by modulating gene expression. A key step in this regulation is the control of transcription, which determines the concentrations of pre-mRNA that are produced. A second level of control involves maturation of pre-mRNAs; many are alternatively spliced, which changes the exon content of transcripts and therefore the ‘message’ of the genes. Recent data indicate that the two control levels are linked. Here, we describe how transcriptional regulators and coregulators influence alternative splicing, with a focus on genes that are controlled by steroid hormones. Recent technical advances that help to elucidate the impact of stimuli on the exon content of regulated gene transcripts are also discussed.

http://www.ncbi.nlm.nih.gov/pubmed/17320409