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© Research
Publication : Comptes rendus biologies

Neuronal replacement in microcircuits of the adult olfactory system

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus biologies - 22 Feb 2007

Lledo PM, Lazarini F

Link to Pubmed [PMID] – 17631446

C. R. Biol. 2007 Jun-Jul;330(6-7):510-20

The local-circuit inhibitory interneurons containing gamma-aminobutyric acid (GABA) are continuously replaced in the adult olfactory bulb. Here, we describe how the production of new GABAergic interneurons is adapted to experience-induced plasticity. In particular, we discuss how such an adaptation is sensitive to the level of sensory inputs and how, in turn, neurogenesis may adjust the neural network functioning to optimize processing of sensory information. Finally, this review brings together recently described properties of interneurons as well as emerging principles of their functions that indicate a much more complex role for these cells than just that of gatekeepers providing inhibition.

http://www.ncbi.nlm.nih.gov/pubmed/17631446