Link to Pubmed [PMID] – 23632795
Eur. J. Hum. Genet. 2013 Nov;21(11):1191-6
Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.