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© Research
Publication : Cluster of COVID-19 in northern France: A retrospective closed cohort study

Cluster of COVID-19 in northern France: A retrospective closed cohort study

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cluster of COVID-19 in northern France: A retrospective closed cohort study - 23 Apr 2020

A. Fontanet, L. Tondeur, Y. Madec, R. Grant, C. Besombes, N. Jolly, S. Fernandes Pellerin, M.-N. Ungeheuer, I. Cailleau, L. Kuhmel, S. Temmam, C. Huon, K.-Y. Chen, B. Crescenzo, S. Munier, C. Demeret, L. Grzelak, I. Staropoli, T. Bruel, P. Gallian, S. Cauchemez, S. van der Werf, O. Schwartz, M. Eloit, B. Hoen

Link to DOI [DOI] – 10.1101/2020.04.18.20071134

Background: The Oise department in France has been heavily affected by COVID-19 in early 2020. Methods: Between 30 March and 4 April 2020, we conducted a retrospective closed cohort study among pupils, their parents and siblings, as well as teachers and non-teaching staff of a high-school located in Oise. Participants completed a questionnaire that covered history of fever and/or respiratory symptoms since 13 January 2020 and had blood tested for the presence of anti-SARS-CoV-2 antibodies. The infection attack rate (IAR) was defined as the proportion of participants with confirmed SARS-CoV-2 infection based on antibody detection. Blood samples from two blood donor centres collected between 23 and 27 March 2020 in the Oise department were also tested for presence of anti-SARS-CoV-2 antibodies. Findings: Of the 661 participants (median age: 37 years), 171 participants had anti-SARS-CoV-2 antibodies. The overall IAR was 25.9% (95% confidence interval (CI) = 22.6-29.4), and the infection fatality rate was 0% (one-sided 97.5% CI = 0-2.1). Nine of the ten participants hospitalised since mid-January were in the infected group, giving a hospitalisation rate of 5.3% (95% CI = 2.4-9.8). Anosmia and ageusia had high positive predictive values for SARS-CoV-2 infection (84.7% and 88.1%, respectively). Smokers had a lower IAR compared to non-smokers (7.2% versus 28.0%, P <0.001). The proportion of infected individuals who had no symptoms during the study period was 17.0% (95% CI = 11.2-23.4). The proportion of donors with anti-SARS-CoV-2 antibodies in two nearby blood banks of the Oise department was 3.0% (95% CI = 1.1-6.4). Interpretation: The relatively low IAR observed in an area where SARS-CoV-2 actively circulated weeks before confinement measures indicates that establishing herd immunity will take time, and that lifting these measures in France will be long and complex.

https://www.medrxiv.org/content/10.1101/2020.04.18.20071134v1