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© Research
Publication : PloS one

Clinical, biological and genetic analysis of prepubertal isolated ovarian cyst in 11 girls

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 25 Jun 2010

Brauner R, Bashamboo A, Rouget S, Goulet M, Philibert P, Sarda-Thibault H, Trivin C, Misrahi M, Sultan C, McElreavey K

Link to Pubmed [PMID] – 20593028

PLoS ONE 2010;5(6):e11282

The cause of isolated gonadotropin-independent precocious puberty (PP) with an ovarian cyst is unknown in the majority of cases. Here, we describe 11 new cases of peripheral PP and, based on phenotypes observed in mouse models, we tested the hypothesis that mutations in the GNAS1, NR5A1, LHCGR, FSHR, NR5A1, StAR, DMRT4 and NOBOX may be associated with this phenotype.

http://www.ncbi.nlm.nih.gov/pubmed/20593028