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© Research
Publication : Médecine sciences : M/S

[Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]

Team: Archived: Molecular Mycology
Team: Fungal Biology and Pathogenicity
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Médecine sciences : M/S - 12 Nov 2012

Desjardins A, Coignard-Biehler H, Mahlaoui N, Frange P, Bougnoux ME, Blanche S, Fischer A, Blumental S, Lortholary O

Link to Pubmed [PMID] – 23171900

Med Sci (Paris) 2012 Nov;28(11):963-9

Chronic granulomatous disease is a genetic disorder responsible for a defect in the NADPH oxidase of phagocytic cells. It impairs the oxidative burst necessary to the intracellular inactivation of microorganisms and predisposes to an increased risk of infections by various microorganisms, including fungi like Aspergillus spp. and other less frequently encountered or emerging fungal species. Here we review the genetic basis, pathogenesis and clinical presentation associated with fungal infections in chronic granulomatous disease as well as the current prophylaxis and newly available therapies.