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© Research
Publication : European journal of immunology

Characterization of mouse thoracic duct B lymphocytes. I. Evidence of functional heterogeneity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Oct 1980

Freitas AA, Coutinho AA

Link to Pubmed [PMID] – 7000521

Eur. J. Immunol. 1980 Oct;10(10):772-6

Thoracic duct lymphocytes (TDL) from C3H/Tif and BALB/c mice were studied for their in vitro reactivity to the B cell mitogens lipopolysaccharide (LPS) and lipoprotein (LP). Roughly 4% and 10% of the surface immunoglobulin (Ig)-positive cells in these populations could be stimulated by LPS and LP, respectively, to generate clones of IgM-secreting cells. Among LPS-reactive B cells, roughly 30% developed into clones which also produced IgG3 or IgG2, while only a very small fraction (1-2%) of all precursors could give rise to clones secreting IgG1 and IgA. Freshly collected TDL from some batches of C3H/HeJ mice displayed a high proportion of Ig-containing B cell blasts (5-10%), which did not secrete enough Ig to be detected as plaque-forming cells (PFC). These cells, however, under appropriate culture conditions and stimulated by LP (but not by Nocardia mitogen), differentiated to PFC of the various Ig classes without dividing.

http://www.ncbi.nlm.nih.gov/pubmed/7000521