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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Memórias do Instituto Oswaldo Cruz

Characterization of a Plasmodium falciparium mutant that has deleted the majority of the gametocyte-specific Pf11-1 locus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Memórias do Instituto Oswaldo Cruz - 01 Jan 1992

Scherf A, Petersen C, Carter R, Alano P, Nelson R, Aikawa M, Mattei D, da Silva LP, Leech J

Link to Pubmed [PMID] – 1343731

Mem. Inst. Oswaldo Cruz 1992;87 Suppl 3:91-4

We identified a gametocyte-specific protein of Plasmodium falciparum called Pf11-1 and provide experimental evidence that this molecule is involved in the emergence of gametes of the infected erythrocyte (gametogenesis). A mutant parasite clone, which has deleted over 90% of the Pf11-1 gene locus, was an important control to establish the gametocyte-specific expression of the Pf11-1. Molecular analysis of the Pf11-1 deletion indicates that it is presumably due to a chromosome breakage with subsequent ‘healing’ by the addition of telomeric heptanucleotides. Moreover, similar DNA rearrangements are observed in most of the laboratory isolates during asexual propagation in vitro.

http://www.ncbi.nlm.nih.gov/pubmed/1343731