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© Research
Publication : Glia

Cerebellar defect and impaired motor coordination in mice lacking vimentin

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Glia - 01 Jan 1999

Colucci-Guyon E, Giménez Y Ribotta M, Maurice T, Babinet C, Privat A

Link to Pubmed [PMID] – 9888296

Glia 1999 Jan;25(1):33-43

Vimentin belongs to the family of intermediate filament (IF) proteins. During the nervous system development in mammals, it is transiently expressed in precursor cells of neuronal and glial lineages, and then it is progressively replaced by other types of IF proteins. Surprisingly, mice knock-out for vimentin develop and reproduce without any apparent defects (Colucci-Guyon et al. Cell 79:679-694, 1994). In adult rodents, Bergmann glia (BG) of the cerebellum continue to express vimentin together with glial fibrillary acidic protein (GFAP). A careful analysis of cerebellar morphology and ultrastructure in mutants showed poorly developed and highly abnormal BG, whereas the migration of granular neurons proceeded normally. Moreover, many Purkinje cells (PC) appeared stunted with a loss of spiny branchlets, and some of them were necrotic. Finally, impaired motor coordination was evidenced by behavioral tests. These observations demonstrate a role for vimentin in contributing to the normal development and morphology of BG and reveal a hitherto unreported functional relationship between BG and PC.

http://www.ncbi.nlm.nih.gov/pubmed/9888296