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© Therese Couderc, Marc Lecuit
Publication : Current biology : CB

Centriole duplication: when PLK4 meets Ana2/STIL

Team: Biology of infection
Member: Minhee Kim
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current biology : CB - 03 Nov 2014

Kim M, Fong CS, Tsou MF

Link to Pubmed [PMID] – 25517369

Curr. Biol. 2014 Nov;24(21):R1046-8

Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.