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© Research
Publication : Journal of structural biology

Cell cycle-dependent kinetochore localization of condensin complex in Saccharomyces cerevisiae

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of structural biology - 11 Jan 2008

Bachellier-Bassi S, Gadal O, Bourout G, Nehrbass U

Link to Pubmed [PMID] – 18296067

J. Struct. Biol. 2008 May;162(2):248-59

In budding yeast mitosis is endonuclear and associated with a very limited condensation of the chromosomes. Despite this partial chromosomal condensation, condensin is conserved and essential for the Saccharomyces cerevisiae mitotic cycle. Here, we investigate the localization of condensin during the mitotic cycle. In addition to a constitutive association with rDNA, we have discovered that condensin is localized to the kinetochore in a cell cycle-dependent manner. Shortly after duplication of the spindle pole body, the yeast equivalent of the centrosome, we observed a local enrichment of condensin colocalizing with kinetochore components. This specific association is consistent with mutant phenotypes of chromosome loss and defective sister chromatid separation at anaphase. During a short period of the cell cycle, we observed, at the single cell level, a spatial proximity of condensin and a cohesin rosette, without colocalization. Furthermore, using a genetic screen we demonstrated that condensin localization at kinetochores is specifically impaired in a mutant for ulp2/smt4, an abundant SUMO protease. In conclusion, during chromosome segregation, we established a SUMO-dependent cell cycle-specific condensin concentration colocalizing with kinetochores.

http://www.ncbi.nlm.nih.gov/pubmed/18296067