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© Tessa Quax, David Prangishvili, Gerard Pehau-Arnaudet, Jean-Marc Panaud
VAPs (virus-associated pyramids) formed by the Sulfolobus islandicus rod-shaped virus 2 (SIRV2) in cells of its hyperthermophilic archaeal host. Negative contrast electron micrography.
Publication : Current opinion in microbiology

Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 01 May 2017

Krupovic M, Béguin P, Koonin EV

Link to Pubmed [PMID] – 28472712

Curr. Opin. Microbiol. 2017 May;38:36-43

A casposon, a member of a distinct superfamily of archaeal and bacterial self-synthesizing transposons that employ a recombinase (casposase) homologous to the Cas1 endonuclease, appears to have given rise to the adaptation module of CRISPR-Cas systems as well as the CRISPR repeats themselves. Comparison of the mechanistic features of the reactions catalyzed by the casposase and the Cas1-Cas2 heterohexamer, the CRISPR integrase, reveals close similarity but also important differences that explain the requirement of Cas2 for integration of short DNA fragments, the CRISPR spacers.

https://www.ncbi.nlm.nih.gov/pubmed/28472712