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© Mart Krupovic, Junfeng Liu
Scanning electron micrograph of Saccharolobus islandicus cells (light blue) infected with the lemon-shaped virus STSV2 (yellow). Artistic rendering by Ala Krupovic.
Publication : Current opinion in microbiology

Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery

Team: Archaeal Virology
Member: Mart Krupovic
Member: Pierre Beguin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 01 May 2017

Krupovic M, Béguin P, Koonin EV

Link to Pubmed [PMID] – 28472712

Curr. Opin. Microbiol. 2017 May;38:36-43

A casposon, a member of a distinct superfamily of archaeal and bacterial self-synthesizing transposons that employ a recombinase (casposase) homologous to the Cas1 endonuclease, appears to have given rise to the adaptation module of CRISPR-Cas systems as well as the CRISPR repeats themselves. Comparison of the mechanistic features of the reactions catalyzed by the casposase and the Cas1-Cas2 heterohexamer, the CRISPR integrase, reveals close similarity but also important differences that explain the requirement of Cas2 for integration of short DNA fragments, the CRISPR spacers.