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© Research
Publication : Haematologica

Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Haematologica - 10 Mar 2009

Barbier S, Chatre L, Bras M, Sancho P, Roué G, Virely C, Yuste VJ, Baudet S, Rubio M, Esquerda JE, Sarfati M, Merle-Béral H, Susin SA

Link to Pubmed [PMID] – 19278964

Haematologica 2009 Apr;94(4):507-17

Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death. In chronic lymphocytic leukemia, CD47 ligation induces one of these alternative forms of cell death: type III programmed cell death. This poorly understood process is characterized by cytoplasmic hallmarks, such as mitochondrial damage. To gain insights into the molecular pathways regulating type III programmed cell death in chronic lymphocytic leukemia, we performed extensive biochemical and cell biology assessments.

http://www.ncbi.nlm.nih.gov/pubmed/19278964