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© Research
Publication : Trends in parasitology

Can transgenic mosquitoes afford the fitness cost?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in parasitology - 27 Dec 2007

Lambrechts L, Koella JC, Boëte C

Link to Pubmed [PMID] – 18164248

Trends Parasitol. 2008 Jan;24(1):4-7

In a recent study, SM1-transgenic Anopheles stephensi, which are resistant partially to Plasmodium berghei, had higher fitness than non-transgenic mosquitoes when they were maintained on Plasmodium-infected blood. This result should be interpreted cautiously with respect to malaria control using transgenic mosquitoes because, despite the evolutionary advantage conferred by the transgene, a concomitant cost prevents it from invading the entire population. Indeed, for the spread of a resistance transgene in a natural situation, the transgene’s fitness cost and the efficacy of the gene drive will be more crucial than any evolutionary advantage.

http://www.ncbi.nlm.nih.gov/pubmed/18164248