Link to Pubmed [PMID] – 31167132 Cell Rep. 2019 Jun 4;27(10):2847-2858.e4. Using p53-deficient T cell lymphoma mouse models, Bianchi et al. show that breakage-fusion-bridge events trigger complex focal genome rearrangements and amplifications in developmentally arrested lymphoblastic cells leading to unique genome and transcriptome signatures found in some human hematological cancers.
