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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : The Journal of organic chemistry

Blockwise approach to fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a: convergent Synthesis of a decasaccharide representative of a dimer of the branched repeating unit

Team: Chemistry of Biomolecules
Team: Archived: Group: Armelle Phalipon
Team: Archived: Molecular Microbial Pathogenesis
Member: Laurence Mulard
Member: Armelle Phalipon
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of organic chemistry - 20 Feb 2004

Bélot F, Wright K, Costachel C, Phalipon A, Mulard LA

Link to Pubmed [PMID] – 14961653

J. Org. Chem. 2004 Feb;69(4):1060-74

The D’A’B'(E’)C’DAB(E)C decasaccharide representative of a dimer of a frame-shifted pentasaccharide repeating unit of the O-specific polysaccharide of Shigella flexneri 2a was synthesized as its methyl glycoside by condensing a pentasaccharide donor (D’A’B'(E’)C’) and a pentasaccharide acceptor (DAB(E)C-OMe). Several convergent routes to these two building blocks, involving either the AB linkage or the BC linkage as the disconnection site, were evaluated in comparison to the linear strategy. The latter was preferred. It is based on the use of the trichloroacetimidate chemistry. The target branched oligosaccharide was designed to probe the recognition at the molecular level of the natural polysaccharide by protective monoclonal antibodies.