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© Research
Publication : Nature reviews. Molecular cell biology

Biased segregation of DNA and centrosomes: moving together or drifting apart?

Team: Stem Cells And Development
Member: Shahragim Tajbakhsh
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Molecular cell biology - 01 Nov 2009

Tajbakhsh S, Gonzalez C

Link to Pubmed [PMID] – 19851338

Nat. Rev. Mol. Cell Biol. 2009 Nov;10(11):804-10

Old and newly synthesized centrosomes have different microtubule nucleating abilities and they contribute to cell polarity when they migrate to opposite poles during cell division. The asymmetric localization of epigenetic marks and kinetochore proteins could lead to the differential recognition of sister chromatids and the biased segregation of DNA strands to daughter cells during cell division. We propose that this asymmetric localization is linked to biased chromatid segregation, which might also be related to the acquisition of distinct cell fates after mitosis.