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© Research
Publication : Autophagy

Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Autophagy - 01 Jan 2015

Moreau P, Moreau K, Segarra A, Tourbiez D, Travers MA, Rubinsztein DC, Renault T

Link to Pubmed [PMID] – 25714877

Autophagy 2015;11(3):516-26

Recent mass mortality outbreaks around the world in Pacific oysters, Crassostrea gigas, have seriously affected the aquaculture economy. Although the causes for these mortality outbreaks appear complex, infectious agents are involved. Two pathogens are associated with mass mortality outbreaks, the virus ostreid herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe the interactions between these 2 pathogens and autophagy, a conserved intracellular pathway playing a key role in innate immunity. We show for the first time that autophagy pathway is present and functional in Pacific oysters and plays an important role to protect animals from infections. This study contributes to better understand the innate immune system of Pacific oysters.

http://www.ncbi.nlm.nih.gov/pubmed/25714877