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© Marie-Christine Prévost, Anne Derbise
Bactéries Yersinia pestis en microscopie electronique à balayage.
Publication : Biomolecules

Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic Yersinia Species.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biomolecules - 04 Dec 2020

Lemarignier M, Pizarro-Cerdá J,

Link to Pubmed [PMID] – 33291818

Link to DOI – E163710.3390/biom10121637

Biomolecules 2020 Dec; 10(12):

Yersinia pseudotuberculosis, Y. enterocolitica and Y. pestis are pathogenic bacteria capable of causing disease in humans by growing extracellularly in lymph nodes and during systemic infections. While the capacity of these bacteria to invade, replicate, and survive within host cells has been known for long, it is only in recent years that their intracellular stages have been explored in more detail. Current evidence suggests that pathogenic Yersinia are capable of activating autophagy in both phagocytic and epithelial cells, subverting autophagosome formation to create a niche supporting bacterial intracellular replication. In this review, we discuss recent results opening novel perspectives to the understanding of intimate host-pathogens interactions taking place during enteric yersiniosis and plague.

https://pubmed.ncbi.nlm.nih.gov/33291818