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© Institut Pasteur
Corne d'Ammon (ou hippocampe) de renard atteint de rage sauvage. Coloration avec un conjugué fluorescent sur la nucléocapside du virus.
Publication : Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Aspergillus spp. invasive external otitis: favourable outcome with a medical approach

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 21 Jan 2016

Marchionni E, Parize P, Lefevre A, Vironneau P, Bougnoux ME, Poiree S, Coignard-Biehler H, DeWolf SE, Amazzough K, Barchiesi F, Jullien V, Alanio A, Garcia-Hermoso D, Wassef M, Kania R, Lortholary O, Lanternier F

Link to Pubmed [PMID] – 26802213

Clin. Microbiol. Infect. 2016 May;22(5):434-7

Aspergillus spp. invasive external otitis (IEO) is a rare infection. We performed a seven-year, single-centre retrospective study from 2007 to 2014 including all patients with proven Aspergillus spp. IEO. Twelve patients were identified. All patients had a poorly controlled diabetes mellitus and one underwent solid organ transplant. The most frequently isolated species was Aspergillus flavus (n = 10) and voriconazole was the first-line therapy in all cases, with a median length of treatment of 338.5 days (158-804 days). None of the patients underwent extensive surgery. The clinical outcome was excellent. However, otological sequelae were reported, including hearing impairment (n = 7) and facial palsy (n = 3).

https://www.ncbi.nlm.nih.gov/pubmed/26802213