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© Research
Publication : Chemical Communications

Artificial nucleotide codons for enzymatic DNA synthesis

Team: Bioorganic chemistry of nucleic acids
Member: Nazarii Sabat
Member: Marcel Hollenstein
Member: Marie Flamme
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Chemical Communications - 15 Nov 2023

Nazarii Sabat, Andreas Stämpfli, Marie Flamme, Steven Hanlon, Serena Bisagni, Filippo Sladojevich, Kurt Püntener, and Marcel Hollenstein*

Link to DOI – 10.1039/D3CC04933G

Chem. Commun., 2023,59, 14547-14550

Herein, we report the high-yielding solid-phase synthesis of unmodified and chemically modified trinucleotide triphosphates (dN3TPs). These synthetic codons can be used for enzymatic DNA synthesis provided their scaffold is stabilized with phosphorothioate units. Enzymatic synthesis with three rather than one letter nucleotides will be useful to produce xenonucleic acids (XNAs) and for in vitro selection of modified functional nucleic acids.