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© William Beaucardet
Reportage Unité Intéractions bactéries cellules
Publication : PLoS neglected tropical diseases

Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B

Team: Clinical Investigation Platform ICAReB-Clin
Member: Olivier Lortholary
Member: Caroline Charlier-Woerther
Member: Fanny Lanternier
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PLoS neglected tropical diseases - 06 Jan 2016

Morizot G, Jouffroy R, Faye A, Chabert P, Belhouari K, Calin R, Charlier C, Miailhes P, Siriez JY, Mouri O, Yera H, Gilquin J, Tubiana R, Lanternier F, Mamzer MF, Legendre C, Peyramond D, Caumes E, Lortholary O, Buffet P

Link to Pubmed [PMID] – 26735920

PLoS Negl Trop Dis 2016 Jan;10(1):e0004304

We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.