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© Therese Couderc, Marc Lecuit
Publication : Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Antibodies to VP1 of swine pasivirus in humans without evidence of transmission from a pig source

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 03 Jun 2015

Arnold F, Hober D, Chaussade H, Dumarest M, Sané F, Nowakowsjki M, Rigaud E, Bellalou J, Desailloud R, Coursaget P, Eloit M

Link to Pubmed [PMID] – 26209375

J. Clin. Virol. 2015 Aug;69:36-9

BACKGROUND: Swine pasivirus (SPaV1) is a recently described enteric virus close to human parechoviruses and highly prevalent in pigs. Antibodies to Escherichia coli-expressed VP1 of SpaV1 have been found in a majority of humans in China.

OBJECTIVES: The objectives were to estimate the antibody prevalence in a European country, to test if exposure to the virus was linked to pig products and if this exposure was a risk factor for the development of diabetes type 1.

STUDY DESIGN: An ELISA test was developed and used to screen 842 healthy subjects with known exposure to pig products, 39 patients with diabetes type 1 and 20 controls.

RESULTS: We identified a high seroprevalence (15.6%) reacting to VP1 of SPaV1 among healthy human subjects. Analysis of risk factors argues against cross-species transmission from pigs as the source of infection. Data also indicate that the presence of SPaV1 VP1-binding antibodies is not associated with diabetes type 1 in humans.

CONCLUSION: Our results suggest that the seroreactivity frequently found in humans against SpaV1 is due to cross-reactivity with related antigen, perhaps a picornavirus, and that SpaV1 is not a zoonotic virus.

http://www.ncbi.nlm.nih.gov/pubmed/26209375