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© Andres Alcover
Scanning electron microscopy showing a conjugate formed between a T lymphocyte and an antigen presenting cell. It is worth noting the long shape of the T cell (Tc) polarized towards the antigen presenting cell (APC) and the membrane protrusions that adhere the T lymphocyte to the antigen presenting cell.
Publication : The Journal of rheumatology

Antibodies to vimentin intermediate filaments in sera from patients with SLE and RA: quantitation by solid phase radioimmunoassay

Team: Archived: Lymphocyte Cell Biology
Member: Andres Alcover
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of rheumatology - 01 Apr 1985

Alcover A, Ramirez-Lafita F, Hernandez C, Nieto A, Avila J

Link to Pubmed [PMID] – 3897530

J. Rheumatol. 1985 Apr;12(2):233-6

A solid phase radioimmunoassay was used to quantify levels of antibodies to vimentin intermediate filaments (VIF) of the cytoskeleton in sera from patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Significantly higher levels of these antibodies were found in 52% of the SLE sera studied, compared to 6% in RA sera and 10% of sera from healthy controls. These antibodies include IgG and IgM classes of immunoglobulins. Our results show that high levels of anti-VIF antibodies are more prevalent in SLE sera, whereas no significant differences are found between sera from patients with RA and healthy controls.