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© Research
Publication : Trends in molecular medicine

An Intestinal Inflammasome – The ILC3-Cytokine Tango

Team: Innate Immunity
Member: James Di Santo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in molecular medicine - 07 Mar 2016

Gonçalves P, Di Santo JP

Link to Pubmed [PMID] – 26965960

Trends Mol Med 2016 Apr;22(4):269-71

The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.