Link to Pubmed [PMID] – 30061292
Antimicrob. Agents Chemother. 2018 Jul;
ART-resistant parasites can be evaluated examining polymorphisms in the Kelch () domain. 69 samples from malaria patients were analyzed. All samples were from Brazilian endemic areas of the following states: Acre (n=14), Amapá (n=15), Amazonas (n=30) and Pará (n=10). After DNA alignment with the 3D7 reference sequence all samples were found to be wild-type. These data provide a baseline on and reinforce the pertinence of ACTs treatment in Brazilian areas.