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© Christophe Thomas, Institut Pasteur
Gel d’électrophorèse lors de la purification d’un échantillon protéique
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in - 20 May 2020

Min Wen Ku, François Anne, Philippe Souque, Stéphane Pêtres, Matthieu Prot, Etienne Simon-Loriere, Pierre Charneau, Maryline Bourgine

Ku et al., A Single Dose of NILV-Based Vaccine Provides Rapid and Durable Protection against Zika Virus, MolecularTherapy (2020), https://doi.org/10.1016/j.ymthe.2020.05.016

Zika virus, a member of the Flaviviridae family, is primarily transmitted by infected Aedes species mosquitoes. In 2016, Zika infection emerged as a global health emergency for its explosive spread and the remarkable neurological defects in the developing fetus. Development of a safe and effective Zika vaccine remains a high priority owing to the risk of re-emergence and limited understanding of Zika virus epidemiology. We engineered a non-integrating lentiviralvector(NILV)-based Zika vaccine encoding the consensus pre-membrane and envelope glycoprotein of circulating Zika virus strains. We further evaluated the immunogenicity and protective efficacy of this vaccine in both immunocompromised and immunocompetent mouse models. A single immunization in both mouse models elicited a robust neutralizing antibody titer and afforded full protection against Zika challenge as early as 7 days post-immunization. This NILV-based vaccine also induced a long-lasting immunity when immunized mice were challenged 6 months after immunization. Altogether, our NILV Zika vaccine provides a rapid yet durable protection through a single dose of immunization without extra adjuvant formulation. Our data suggest a promising Zika vaccine candidate for an emergency situation, and demonstrate the capacity of lentiviral vector as an efficient vaccine delivery platform.

https://www.sciencedirect.com/science/article/pii/S1525001620302501?via%3Dihub