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© Research
Publication : Journal of Bacteriology

A new hemophore-dependent heme acquisition system of Serratia marcescens reconstituted in Escherichia coli

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of Bacteriology - 01 Jun 1997

Ghigo J.-M., Létoffé S., Wandersman C.

Link to Pubmed [PMID] – 9171402

J Bacteriol. 1997 Jun;179(11):3572-9.

The utilization by Serratia marcescens of heme bound to hemoglobin requires HasA, an extracellular heme-binding protein. This unique heme acquisition system was studied in an Escherichia coli hemA mutant that was a heme auxotroph. We identified a 92-kDa iron-regulated S. marcescens outer membrane protein, HasR, which alone enabled the E. coli hemA mutant to grow on heme or hemoglobin as a porphyrin source. The concomitant secretion of HasA by the HasR-producing hemA mutant greatly facilitates the acquisition of heme from hemoglobin. This is the first report of a synergy between an outer membrane protein and an extracellular heme-binding protein, HasA, acting as a heme carrier, which we termed a hemophore.

https://www.ncbi.nlm.nih.gov/pubmed/9171402