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© Research
Publication : Scandinavian journal of immunology

A model system for the analysis of B-cell activation and effector T-cell functions. T cell-dependent B-cell responses facilitated by anti-I-A antibodies

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scandinavian journal of immunology - 01 Jan 1989

Pereira P, Bandeira A, Kleine B, Marquez C, Coutinho A, Martinez C

Link to Pubmed [PMID] – 2784218

Scand. J. Immunol. 1989 Jan;29(1):49-56

We have attempted to develop an in vitro system where polyclonal B lymphocyte responses could be induced in ‘antigen-like’ conditions, that is, where surface immunoglobulin-dependent binding mediates interaction with a mitogen. Monoclonal anti-mu and anti-delta antibodies were covalently bound to lipopolysaccharide (LPS) and these complexes were shown to display mitogenic activity. Polyclonal plaque-forming cell (PFC) responses, however, were diminished in cultures stimulated by anti-mu-LPS (but not by anti-delta-LPS) indicating that ‘anti-mu inhibition’ of terminal B-cell differentiation also applies to ‘specific’ antibody responses. Moreover, the analysis of the functional activity of monoclonal antibodies to major histocompatibility complex (MHC) class II molecules revealed a surprising synergy between low, non-stimulatory concentrations of anti-mu-LPS (but not anti-delta-LPS) with anti-I-A antibodies. These responses are T-cell dependent and synergy with anti-mu-LPS conjugates can also be obtained with ‘naturally’ activated CD4+ cells isolated from normal donors. A model of molecular and cellular interactions was derived, which accounts for the present findings and is applicable in antigen-dependent lymphocyte collaboration.

http://www.ncbi.nlm.nih.gov/pubmed/2784218