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© Research
Publication : Journal of biomolecular structure & dynamics

A general procedure for assigning the 31P spectra of drug-oligonucleotide complexes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of biomolecular structure & dynamics - 01 Feb 1988

Delepierre M, Roques BP, Langlois D'Estaintot B, Igolen J

Link to Pubmed [PMID] – 3271496

J. Biomol. Struct. Dyn. 1988 Feb;5(4):933-7

Taking advantage of the slow exchange at the NMR time scale occurring in drug oligonucleotides complexes the 31P signals in the bound forms are assigned by using 31P NMR two dimensional chemical exchange. This technique was applied to complexes between Actinomycin D and d[CpGpCpG] or d[m5CpGpm5CpG]. As compared to the labelled 17O, 18O this method proved to be a powerful and unique way to assign 31P in broad spectrum or with long oligonucleotides.

http://www.ncbi.nlm.nih.gov/pubmed/3271496