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PhD Student
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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
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Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
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Solid-supported ligation primer

The S-antigen of Plasmodium falciparum Palo Alto represents a new S-antigen serotype

Publication : Journal of biomolecular structure & dynamics

A general procedure for assigning the 31P spectra of drug-oligonucleotide complexes

Team: Archived: Nuclear Magnetic Resonance Of Biomolecules

Member: Muriel Delepierre

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Diseases

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Published in Journal of biomolecular structure & dynamics - 01 Feb 1988

Delepierre M, Roques BP, Langlois D'Estaintot B, Igolen J

Link to Pubmed [PMID] – 3271496

J. Biomol. Struct. Dyn. 1988 Feb;5(4):933-7

Taking advantage of the slow exchange at the NMR time scale occurring in drug oligonucleotides complexes the 31P signals in the bound forms are assigned by using 31P NMR two dimensional chemical exchange. This technique was applied to complexes between Actinomycin D and d[CpGpCpG] or d[m5CpGpm5CpG]. As compared to the labelled 17O, 18O this method proved to be a powerful and unique way to assign 31P in broad spectrum or with long oligonucleotides.

http://www.ncbi.nlm.nih.gov/pubmed/3271496

Published on: 01 Feb 1988