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© Research
Publication : Biology direct

A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and Eucarya

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biology direct - 23 Dec 2008

Brochier-Armanet C, Gribaldo S, Forterre P

Link to Pubmed [PMID] – 19105819

Biol. Direct 2008;3:54

DNA topoisomerase IB (TopoIB) was thought for a long time to be a eukaryotic specific enzyme. A shorter version was then found in viruses and later on in several bacteria, but not in archaea. Here, we show that a eukaryotic-like TopoIB is present in the recently sequenced genomes of two archaea of the newly proposed phylum Thaumarchaeota. Phylogenetic analyses suggest that a TopoIB was present in the last common ancestor of Archaea and Eucarya. This finding indicates that the last common ancestor of Archaea and Eucarya may have harboured a DNA genome.

http://www.ncbi.nlm.nih.gov/pubmed/19105819