• 2024
  Rémi Sieskind, Sophia Missoury, Clément Madru, Isciane Commenge, Germain Niogret, Marcel Hollenstein, Yannick Rondelez, Ludovic Sauguet, Ahmed Haouz, Pierre Legrand, Marc Delarue*, Crystal structures of monomeric BsmI restriction endonuclease reveal a coordinated action of its two distinct active sites to sequentially cleave the two DNA strands, Communications Biology.
• 2023
  Betancurt-Anzola L, Martínez-Carranza M, Delarue M, Zatopek KM, Gardner AF, Sauguet L, Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases., Nat Commun 2023 Dec; 14(1): 8306.
• 2023
  Pichard-Kostuch A, Da Cunha V, Oberto J, Sauguet L, Basta T, The universal Sua5/TsaC family evolved different mechanisms for the synthesis of a key tRNA modification, Volume 14 .
• 2023
  Madru C, Martínez-Carranza M, Laurent S, Alberti AC, Chevreuil M, Raynal B, Haouz A, Le Meur RA, Delarue M, Henneke G, Flament D, Krupovic M, Legrand P, Sauguet L, DNA-binding mechanism and evolution of replication protein A., Nat Commun 2023 Apr; 14(1): 2326.
• 2021
  Madru C, Tekpinar AD, Rosario S, Czernecki D, Brûlé S, Sauguet L, Delarue M, Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli., PLoS One 2021 ; 16(4): e0250610.
• 2020
  Zatopek KM, Alpaslan E, Evans TC, Sauguet L, Gardner AF, , Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases., Nucleic Acids Res 2020 12; 48(21): 12204-12218.
• 2020
  Madru C, Henneke G, Raia P, Hugonneau-Beaufet I, Pehau-Arnaudet G, England P, Lindahl E, Delarue M, Carroni M, Sauguet L, , Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA., Nat Commun 2020 03; 11(1): 1591.
• 2019
  Sauguet L, The Extended “Two-Barrel” Polymerases Superfamily: Structure, Function and Evolution, J Mol Biol. 2019 Sep 20;431(20):4167-4183. .
• 2019
  Sauguet L, , The Extended “Two-Barrel” Polymerases Superfamily: Structure, Function and Evolution., J Mol Biol 2019 09; 431(20): 4167-4183.
• 2019
  Raia P, Delarue M, Sauguet L, , An updated structural classification of replicative DNA polymerases., Biochem Soc Trans 2019 02; 47(1): 239-249.
• 2019
  Raia P, Carroni M, Henry E, Pehau-Arnaudet G, Brûlé S,Béguin P, Henneke G, Lindahl E, Delarue M, Sauguet L, Structure of the DP1–DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases, PLOS Biology 17, e3000122 .
• 2019
  Raia P, Carroni M, Henry E, Pehau-Arnaudet G, Brûlé S, Béguin P, Henneke G, Lindahl E, Delarue M, Sauguet L, , Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases., PLoS Biol 2019 01; 17(1): e3000122.
• 2018
  Hu H, Ataka K, Menny A, Fourati Z, Sauguet L, Corringer PJ, Koehl P, Heberle J, Delarue M, Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel, Proc. Natl. Acad. Sci. U.S.A. 2018 12;115(52):E12172-E12181.
• 2018
  Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M, Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels, Cell Rep 2018 04;23(4):993-1004.
• 2018
  Hu H, Nemecz Á, Van Renterghem C, Fourati Z, Sauguet L, Corringer PJ, Delarue M, Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation, Proc. Natl. Acad. Sci. U.S.A. 2018 04;115(17):E3959-E3968.
• 2016
  Luckau S, Wehrs TP, Brandau S, Horn PA, Lindemann M, Vaccination Against Human Papilloma Viruses Leads to a Favorable Cytokine Profile of Specific T Cells, J. Immunother. 2016 10;39(8):316-20.
• 2016
  Sauguet L, Raia P, Henneke G, Delarue M., Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography., Nat Commun. 2016 Aug 22;7:12227.
• 2016
  Ostrowski M, Porowinska D, Prochnicki T, Prevost M, Raynal B, Baron B, Sauguet L, Corringer PJ, Faure G, Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)., Toxicon. 2016 Jun 15;116:63-71..
• 2016
  Laurent B, Murail S, Shahsavar A, Sauguet L, Delarue M, Baaden M, Sites of Anesthetic Inhibitory Action on a Cationic Ligand-Gated Ion Channel, Structure 2016 Apr;24(4):595-605.
• 2016
  Sauguet L, Fourati Z, Prangé T, Delarue M, Colloc'h N, Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel, PLoS ONE 2016;11(2):e0149795.
• 2016
  Sauguet L, Raia P, Henneke G, Delarue M, , Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography., Nat Commun 2016 ; 7(): 12227.
• 2015
  Moraga-Cid G, Sauguet L, Huon C, Malherbe L, Girard-Blanc C, Petres S, Murail S, Taly A, Baaden M, Delarue M, Corringer PJ, , Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure., Proc Natl Acad Sci U S A 2015 Mar; 112(9): 2865-70.
• 2014
  Sauguet L, Shahsavar A, Delarue M, Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels, Biochim. Biophys. Acta 2015 Mar;1850(3):511-23.
• 2013
  Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M, Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation, Proc. Natl. Acad. Sci. U.S.A. 2014 Jan;111(3):966-71.
• 2013
  Sauguet L, Poitevin F, Murail S, Van Renterghem C, Moraga-Cid G, Malherbe L, Thompson AW, Koehl P, Corringer PJ, Baaden M, Delarue M, Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels, EMBO J. 2013 Mar;32(5):728-41.
• 2013
  Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M, Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel, Nat Commun 2013;4:1697.
• 2012
  Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C., Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines, Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. .
• 2012
  Corringer PJ, Poitevin F, Prevost MS, Sauguet L, Delarue M, Changeux JP, Structure and pharmacology of pentameric receptor channels: from bacteria to brain, Structure 2012 Jun;20(6):941-56.
• 2012
  Prevost MS, Sauguet L, Nury H, Van Renterghem C, Huon C, Poitevin F, Baaden M, Delarue M, Corringer PJ, A locally closed conformation of a bacterial pentameric proton-gated ion channel, Nat. Struct. Mol. Biol. 2012 May;19(6):642-9.