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  • nrc
  • whocc
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  • tool
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  • Assistant Professor
  • Associate Professor
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  • Clinical Research Nurse
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  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
04
Jul 2015
Ending Date
04
Dec 2025
Status
Ongoing
Members
2

About

Biological study of secreted dengue virus nonstructural protein NS1

Flavivirus NS1 is involved in the intracellular stages of virus replication. It also circulates in the extracellular medium although its related function remains unknown. We have developed a dengue diagnostic kit based on the NS1 antigen capture by ELISA that has become a reference in the field since its commercialization by BioRad in 2006. We are currently pursuing the functional characterization of the secreted form of dengue virus NS1 in an attempt to specify its contribution to fatal hemorrhagic fevers.