Covid-19 disease is characterized by dysregulated immune response leading to enhanced levels of circulating and lung inflammatory mediators. The latter include cytokines and lipid mediators (LMs) which results from increased phospholipid metabolism. The role of cytokines has been extensively examined but the implication of LMs has received little attention. Alteration of phospholipid metabolism is also associated to a number of pathophysiological processes including hydrolysis of pulmonary surfactant phospholipids and cell death or apoptosis. In the present work we examined in airways aspirates of patients with Covid-19 after their admission to ICU, the changes in the levels of LMs and their possible role in the severity of pulmonary disease of these patients.