Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search

← Go to Research

Go back
Scroll to top
Share
Starting Date
08
Sep 2015
Status
Ongoing
Members
2
Structures
3
Instituts
2
Publications
1

About

Gastric cancer  is the fourth most common malignancy and the third cause of cancer related-death worldwide. Although its incidence and mortality rates have progressively decreased in the last decades, the absolute number of cases is not going to decline in the next future. Gastric cancer  remains an important public health problem. It affects about one-million people per year and it is associated with 800 000 deaths, with a higher incidence in males. Wide geographic variation in gastric cancer survival has been reported, depending mainly on differences in stages of diagnosis. This cancer is often detected at an advanced stage with an overall 5-years survival rate between 10% and 24%, as example in western populations including Europe. Gastric cancer is of multifactorial origin. The major risk factor associated to 80-90% of gastric cancer  cases is Helicobacter pylori infection.  In collaboration with J. Torres in Mexico, where the incidence of H. pylori infection and gastric cancer is high, we have previously identify  mitochondrial DNA level in circulating leukocytes as a biomarker candidate for the detection of patients at risk of gastric cancer development  (Fernandes et al, 2014).                                                                                                                                                                                                  There is no appropriate screening strategies available for global application to reduce the global burden of gastric cancer. Thus, the characterization of biomarkers that would detect earliest the presence of gastric cancer lesions in absence of clinical symptoms is of public health interest. Such biomarkers will  also be useful to monitor disease remission/progression during the treatment. They could also be  an important tool to optimize anti-cancer therapeutic strategies. The aim of our project is to identify and to validate gastric cancer biomarker candidates  in different populations  with high incidence of gastric cancer and high mortality rate due to this cancer. These results will have an impact in clinic and can pave the way for the development of a non-invasive test for an early detection/diagnosis of patients with high risk of gastric cancer.

Fundings