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© Uwe Maskos
Tranche d'hippocampe de souris colorée avec deux toxines spécifiques de sous-types de récepteur nicotinique, en rouge (grains), et en vert (corps cellulaires). L'hippocampe est la zone du cerveau qui gère la mémoire spatiale.
News

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Team: Integrative Neurobiology of Cholinergic Systems
Member: Uwe Maskos

In our study published in Nature Medicine (Koukouli et al. 2017), we showed that human mutations of nicotinic receptors associated with psychiatric disorders modulate hypofrontality through a hierarchical circuit of inhibitory neurons and chronic nicotine administration reverses this hypofrontality. This finding paves the way to new therapeutic strategies targeting nicotinic receptors in mental disorders.

Press release: https://www.pasteur.fr/en/how-nicotine-acts-brains-schizophrenic-patients 

Nature Medicine News and Views: http://www.nature.com/nm/journal/v23/n3/full/nm.4300.html