Born and raised in Paris and its suburban area, I did my master degree at Paris 6 (Université Pierre et Marie Curie), and participated to the Pasteur course “Advanced Immunology” during my M2. My master internship was in Ana Cumano’s laboratory (Unit for Lymphopoiesis), where I studied the characteristics of the two waves of progenitors that colonize the fetal thymus during embryogenesis. After that I moved to London to do my PhD in Frederic Geissmann’s laboratory (now in the Memorial Sloan Kettering Cancer Center, where I did the second half of my PhD). There, I studied the development of monocytes and the dynamics of their progenitors in the bone marrow in mice. I also studied the functions of kidney resident macrophages and their response to circulating immune complexes. I joined Dr Quintin’s laboratory in June 2018, and we will use mouse models to study the mechanisms through which innate immune cells and their progenitors are impacted by fungi or fungal components, in the context of innate immune training.
Innate immunological imprinting induced by fungal encounters
The immune system is composed of two arms: the innate and adaptive immunity. Until recently, the adaptive immune system was considered the only mediator of immune memory. However, we and others demonstrated that innate […]
Since June 2018
Postdoctorate in Jessica Quintin’s laboratory at Institut Pasteur (Paris). Studying innate immune training in vivo, using murine models.
Oct 2013-Fev 2018
PhD in Frédéric Geissmann’s laboratory, under his supervision, at King’s College (London), then at Memorial Sloan Kettering Cancer Center (New York). Collaboration with Grégoire Altan-Bonnet’s group (NIH, Washington) to use an in silico model allowing a better understanding of monocyte development, notably the Ly6C-low subset. Second project aiming at caracterising kidney resident macrophage response to circulating immune complexes, by intravital microscopy and flow cytometry.
Master 2 internship at Institut Pasteur, in Ana Cumano’s laboratory, under Ana Cumano’s and Pablo Pereira’s supervision. Characterisation of the two waves of progenitors colonising the foetal thymus during embryogenesis.
Internship at Institut Pasteur, in Ana Cumano’s laboratory (Unit for Lymphopoiesis), under her supervision. Study of a population of stromal cells in the foetal liver potentially involved in hematopoietic stem cell expansion during embryogenesis.
Master 1 internship at Institut Cochin, in Anne Hosmalin’s laboratory, under the supervision of Agnès Le Bon and Kahina Taleb. Studying the effects of type I interferon on dendritic cell homeostasis.
Internship at the Centre de Recherche des Cordeliers, in Srinivas Kaveri’s laboratory,under the supervision of Yann Meslier and Sébastien Lacroix-Desmazes. Production and purification of monoclonal antibodies, in the context of a projet aiming at establishing, via materno-foetal transfer, a tolerance towards therapeutic coagulation factor VIII for hemophilia A.
2018: PhD in Immunology, King’s College (London)
2013: Masters degree in Immunology, University Pierre et Marie Curie (Paris 6)
2011: Licence Biomédicale (Bachelor degree), University René Descartes (Paris 5)
2008-2010: Preparatory Class for Engeneering Schools, “Maths Sup/Spé, section BCPST”, Louis Thuillier high school, Amiens.
2020β-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies., J Clin Invest 2020 09; 130(9): 4561-4573.
2019Developmental origin, functional maintenance and genetic rescue of osteoclasts, Nature. 2019 Apr;568(7753):541-545. doi: 10.1038/s41586-019-1105-7. Epub 2019 Apr 10..
2016Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages, Cell 2016 Aug;166(4):991-1003.